1THE
CRYSTAL STRUCTURES OF RECOMBINANT RAT CATHEPSIN B AND A CATHEPSIN B-INHIBITOR COMPLEX: IMPLICATIONS FOR STRUCTURE-BASED INHIBITOR DESIGN
Summary for 1THE
Entry DOI | 10.2210/pdb1the/pdb |
Related PRD ID | PRD_000253 |
Descriptor | Cathepsin B, amino{[(4S)-4-{[(benzyloxy)carbonyl]amino}-5-{[(2S)-1-(benzyloxy)-4-chloro-3-oxobutan-2-yl]amino}-5-oxopentyl]amino}methaniminium (3 entities in total) |
Functional Keywords | thiol protease, glycoprotein, protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Rattus norvegicus (brown rat,rat,rats) |
Cellular location | Lysosome: P00787 |
Total number of polymer chains | 2 |
Total formula weight | 57921.15 |
Authors | Huber, C.P.,Jia, Z. (deposition date: 1995-09-15, release date: 1996-03-10, Last modification date: 2012-12-12) |
Primary citation | Jia, Z.,Hasnain, S.,Hirama, T.,Lee, X.,Mort, J.S.,To, R.,Huber, C.P. Crystal structures of recombinant rat cathepsin B and a cathepsin B-inhibitor complex. Implications for structure-based inhibitor design. J.Biol.Chem., 270:5527-5533, 1995 Cited by PubMed: 7890671DOI: 10.1074/jbc.270.10.5527 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
Download full validation report