1THE

CRYSTAL STRUCTURES OF RECOMBINANT RAT CATHEPSIN B AND A CATHEPSIN B-INHIBITOR COMPLEX: IMPLICATIONS FOR STRUCTURE-BASED INHIBITOR DESIGN

1THE の概要

• エントリーDOI: 10.2210/pdb1the/pdb
• 関連するBIRD辞書のPRD_ID: PRD_000253
• 分子名称: Cathepsin B, amino{[(4S)-4-{[(benzyloxy)carbonyl]amino}-5-{[(2S)-1-(benzyloxy)-4-chloro-3-oxobutan-2-yl]amino}-5-oxopentyl]amino}met haniminium (3 entities in total)
• 機能のキーワード: thiol protease, glycoprotein, protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Rattus norvegicus (brown rat,rat,rats)
• 細胞内の位置: Lysosome: P00787
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 57921.15

構造登録者

Huber, C.P.,Jia, Z. (登録日: 1995-09-15, 公開日: 1996-03-10, 最終更新日: 2024-06-05)

• 主引用文献: Jia, Z.,Hasnain, S.,Hirama, T.,Lee, X.,Mort, J.S.,To, R.,Huber, C.P.; Crystal structures of recombinant rat cathepsin B and a cathepsin B-inhibitor complex. Implications for structure-based inhibitor design.; J.Biol.Chem., 270:5527-5533, 1995; PubMed: 7890671; DOI: 10.1074/jbc.270.10.5527

実験手法

X-RAY DIFFRACTION (1.9 Å)