1TFX

COMPLEX OF THE SECOND KUNITZ DOMAIN OF TISSUE FACTOR PATHWAY INHIBITOR WITH PORCINE TRYPSIN

Summary for 1TFX

Entry DOI	10.2210/pdb1tfx/pdb
Descriptor	TRYPSIN, TISSUE FACTOR PATHWAY INHIBITOR, CALCIUM ION, ... (4 entities in total)
Functional Keywords	complex (serine protease-inhibitor), hydrolase, inhibitor, blood coagulation, complex (serine protease-inhibitor) complex, complex (serine protease/inhibitor)
Biological source	Sus scrofa (pig) More
Cellular location	Secreted, extracellular space: P00761 Secreted: P10646
Total number of polymer chains	4
Total formula weight	60774.48
Authors	Stubbs, M.T.,Huber, R. (deposition date: 1997-01-21, release date: 1998-01-21, Last modification date: 2023-08-09)
Primary citation	Burgering, M.J.,Orbons, L.P.,van der Doelen, A.,Mulders, J.,Theunissen, H.J.,Grootenhuis, P.D.,Bode, W.,Huber, R.,Stubbs, M.T. The second Kunitz domain of human tissue factor pathway inhibitor: cloning, structure determination and interaction with factor Xa. J.Mol.Biol., 269:395-407, 1997 Cited by PubMed: 9199408 DOI: 10.1006/jmbi.1997.1029 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation