1TDJ

THREONINE DEAMINASE (BIOSYNTHETIC) FROM E. COLI

1TDJ の概要

• エントリーDOI: 10.2210/pdb1tdj/pdb
• 分子名称: BIOSYNTHETIC THREONINE DEAMINASE, PYRIDOXAL-5'-PHOSPHATE (3 entities in total)
• 機能のキーワード: allostery, cooperative, tetramer, regulation, pyridoxal phosphate, isoleucine biosynthesis
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 56510.21

構造登録者

Gallagher, D.T.,Gilliland, G.L.,Xiao, G.,Eisenstein, E. (登録日: 1998-03-27, 公開日: 1998-10-14, 最終更新日: 2025-03-26)

主引用文献

Gallagher, D.T.,Gilliland, G.L.,Xiao, G.,Zondlo, J.,Fisher, K.E.,Chinchilla, D.,Eisenstein, E.
Structure and control of pyridoxal phosphate dependent allosteric threonine deaminase.
Structure, 6:465-475, 1998

PubMed Abstract: Feedback inhibition of biosynthetic threonine deaminase (TD) from Escherichia coli provided one of the earliest examples of protein-based metabolic regulation. Isoleucine, the pathway end-product, and valine, the product of a parallel pathway, serve as allosteric inhibitor and activator, respectively. This enzyme is thus a useful model system for studying the structural basis of allosteric control mechanisms.

PubMed: 9562556
DOI: 10.1016/S0969-2126(98)00048-3

実験手法

X-RAY DIFFRACTION (2.8 Å)