1TB6
2.5A Crystal Structure of the Antithrombin-Thrombin-Heparin Ternary Complex
Summary for 1TB6
Entry DOI | 10.2210/pdb1tb6/pdb |
Descriptor | thrombin, Antithrombin-III, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total) |
Functional Keywords | heparin, hydrolase-blood clotting complex, hydrolase/blood clotting |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 3 |
Total formula weight | 92162.06 |
Authors | Li, W.,Johnson, D.J.,Esmon, C.T.,Huntington, J.A. (deposition date: 2004-05-19, release date: 2004-08-17, Last modification date: 2023-08-23) |
Primary citation | Li, W.,Johnson, D.J.,Esmon, C.T.,Huntington, J.A. Structure of the antithrombin-thrombin-heparin ternary complex reveals the antithrombotic mechanism of heparin. Nat.Struct.Mol.Biol., 11:857-862, 2004 Cited by PubMed: 15311269DOI: 10.1038/nsmb811 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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