1TB0

Effect of Shuttle Location and pH Environment on H+ Transfer in Human Carbonic Anhydrase II

1TB0 の概要

• エントリーDOI: 10.2210/pdb1tb0/pdb
• 関連するPDBエントリー: 1T9N 1TBT 1TE3 1TEQ 1TEU
• 分子名称: Carbonic anhydrase II, ZINC ION, CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: proton shuttle carbonic anhydrase metalloenzyme, lyase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm : P00918
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29389.92

構造登録者

Fisher, Z.,Hernandez Prada, J.A.,Tu, C.,Duda, D.,Yoshioka, C.,An, H.,Govindasamy, L.,Silverman, D.N.,McKenna, R. (登録日: 2004-05-19, 公開日: 2005-01-25, 最終更新日: 2023-08-23)

• 主引用文献: Fisher, Z.,Hernandez Prada, J.A.,Tu, C.,Duda, D.,Yoshioka, C.,An, H.,Govindasamy, L.,Silverman, D.N.,McKenna, R.; Structural and kinetic characterization of active-site histidine as a proton shuttle in catalysis by human carbonic anhydrase II.; Biochemistry, 44:1097-1105, 2005; PubMed: 15667203; DOI: 10.1021/bi0480279

実験手法

X-RAY DIFFRACTION (2 Å)