1TAG

STRUCTURAL DETERMINANTS FOR ACTIVATION OF THE ALPHA-SUBUNIT OF A HETEROTRIMERIC G PROTEIN

Summary for 1TAG

Entry DOI	10.2210/pdb1tag/pdb
Descriptor	TRANSDUCIN-ALPHA, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... (4 entities in total)
Functional Keywords	gtp-binding protein, g-protein, gtpase, transducin
Biological source	Bos taurus (cattle)
Total number of polymer chains	1
Total formula weight	37608.97
Authors	Lambright, D.G.,Noel, J.P.,Hamm, H.E.,Sigler, P.B. (deposition date: 1994-11-23, release date: 1995-02-07, Last modification date: 2024-02-14)
Primary citation	Lambright, D.G.,Noel, J.P.,Hamm, H.E.,Sigler, P.B. Structural determinants for activation of the alpha-subunit of a heterotrimeric G protein. Nature, 369:621-628, 1994 Cited by PubMed Abstract: The 1.8 A crystal structure of transducin alpha.GDP, when compared to that of the activated complex with GTP-gamma S, reveals the nature of the conformational changes that occur on activation of a heterotrimeric G-protein alpha-subunit. Structural changes initiated by direct contacts with the terminal phosphate of GTP propagate to regions that have been implicated in effector activation. The changes are distinct from those observed in other members of the GTPase superfamily. PubMed: 8208289 DOI: 10.1038/369621a0 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation