1TAG

STRUCTURAL DETERMINANTS FOR ACTIVATION OF THE ALPHA-SUBUNIT OF A HETEROTRIMERIC G PROTEIN

1TAG の概要

• エントリーDOI: 10.2210/pdb1tag/pdb
• 分子名称: TRANSDUCIN-ALPHA, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... (4 entities in total)
• 機能のキーワード: gtp-binding protein, g-protein, gtpase, transducin
• 由来する生物種: Bos taurus (cattle)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37608.97

構造登録者

Lambright, D.G.,Noel, J.P.,Hamm, H.E.,Sigler, P.B. (登録日: 1994-11-23, 公開日: 1995-02-07, 最終更新日: 2024-02-14)

主引用文献

Lambright, D.G.,Noel, J.P.,Hamm, H.E.,Sigler, P.B.
Structural determinants for activation of the alpha-subunit of a heterotrimeric G protein.
Nature, 369:621-628, 1994

PubMed Abstract: The 1.8 A crystal structure of transducin alpha.GDP, when compared to that of the activated complex with GTP-gamma S, reveals the nature of the conformational changes that occur on activation of a heterotrimeric G-protein alpha-subunit. Structural changes initiated by direct contacts with the terminal phosphate of GTP propagate to regions that have been implicated in effector activation. The changes are distinct from those observed in other members of the GTPase superfamily.

PubMed: 8208289
DOI: 10.1038/369621a0

実験手法

X-RAY DIFFRACTION (1.8 Å)