1T27

THE STRUCTURE OF PITP COMPLEXED TO PHOSPHATIDYLCHOLINE

「1FVZ」から置き換えられました

1T27 の概要

• エントリーDOI: 10.2210/pdb1t27/pdb
• 分子名称: Phosphatidylinositol transfer protein alpha isoform, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE (3 entities in total)
• 機能のキーワード: lipid binding protein
• 由来する生物種: Rattus norvegicus (Norway rat)
• 細胞内の位置: Cytoplasm: P16446
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 32742.57

構造登録者

Yoder, M.D.,Thomas, L.M.,Tremblay, J.M.,Oliver, R.L.,Yarbrough, L.R.,Helmkamp Jr., G.M. (登録日: 2004-04-20, 公開日: 2004-05-11, 最終更新日: 2024-02-14)

主引用文献

Yoder, M.D.,Thomas, L.M.,Tremblay, J.M.,Oliver, R.L.,Yarbrough, L.R.,Helmkamp Jr., G.M.
STRUCTURE OF A MULTIFUNCTIONAL PROTEIN. MAMMALIAN PHOSPHATIDYLINOSITOL TRANSFER PROTEIN COMPLEXED WITH PHOSPHATIDYLCHOLINE
J.Biol.Chem., 276:9246-9252, 2001

PubMed Abstract: Eukaryotic phosphatidylinositol transfer protein is a ubiquitous multifunctional protein that transports phospholipids between membrane surfaces and participates in cellular phospholipid metabolism during signal transduction and vesicular trafficking. The three-dimensional structure of the alpha-isoform of rat phosphatidylinositol transfer protein complexed with one molecule of phosphatidylcholine, one of its physiological ligands, has been determined to 2.2 A resolution by x-ray diffraction techniques. A single beta-sheet and several long alpha-helices define an enclosed internal cavity in which a single molecule of the phospholipid is accommodated with its polar head group in the center of the protein and fatty acyl chains projected toward the surface. Other structural features suggest mechanisms by which cytosolic phosphatidylinositol transfer protein interacts with membranes for lipid exchange and associates with a variety of lipid and protein kinases.

PubMed: 11104777
DOI: 10.1074/jbc.M010131200

実験手法

X-RAY DIFFRACTION (2.2 Å)