1SWM

X-RAY CRYSTAL STRUCTURE OF THE FERRIC SPERM WHALE MYOGLOBIN: IMIDAZOLE COMPLEX AT 2.0 ANGSTROMS RESOLUTION

1SWM の概要

• エントリーDOI: 10.2210/pdb1swm/pdb
• 分子名称: MYOGLOBIN, AZIDE ION, SULFATE ION, ... (5 entities in total)
• 機能のキーワード: oxygen transport
• 由来する生物種: Physeter catodon (sperm whale)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 17989.52

構造登録者

Rizzi, M.,Ascenzi, P.,Coda, A.,Brunori, M.,Bolognesi, M. (登録日: 1992-03-03, 公開日: 1994-01-31, 最終更新日: 2024-02-14)

主引用文献

Lionetti, C.,Guanziroli, M.G.,Frigerio, F.,Ascenzi, P.,Bolognesi, M.
X-ray crystal structure of the ferric sperm whale myoglobin: imidazole complex at 2.0 A resolution.
J.Mol.Biol., 217:409-412, 1991

PubMed Abstract: The X-ray crystal structure of the ferric sperm whale (Physeter catodon) myoglobin:imidazole complex has been refined at 2.0 A resolution, to a final R-factor of 14.8%. The overall conformation of the protein is little affected by binding of the ligand. Imidazole is co-ordinated to the heme iron at the distal site, and forces distinguishable local changes in the surrounding protein residues. His64(E7) swings out of the distal pocket and becomes substantially exposed to the solvent: nevertheless, it stabilizes the exogenous ligand by hydrogen bonding. The side-chains of residues Arg45(CD3) and Asp60(E3) are also affected by imidazole association.

PubMed: 1994031
DOI: 10.1016/0022-2836(91)90744-Q

実験手法

X-RAY DIFFRACTION (1.8 Å)