1SUR

PHOSPHO-ADENYLYL-SULFATE REDUCTASE

1SUR の概要

• エントリーDOI: 10.2210/pdb1sur/pdb
• 分子名称: PAPS REDUCTASE (1 entity in total)
• 機能のキーワード: assimilatory sulfate reduction, 3-phospho-adenylyl-sulfate reductase, oxidoreductase
• 由来する生物種: Escherichia coli
• 細胞内の位置: Cytoplasm: P17854
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 24595.89

構造登録者

Sinning, I.,Savage, H. (登録日: 1998-04-01, 公開日: 1999-05-11, 最終更新日: 2024-02-14)

主引用文献

Savage, H.,Montoya, G.,Svensson, C.,Schwenn, J.D.,Sinning, I.
Crystal structure of phosphoadenylyl sulphate (PAPS) reductase: a new family of adenine nucleotide alpha hydrolases.
Structure, 5:895-906, 1997

PubMed Abstract: Assimilatory sulphate reduction supplies prototrophic organisms with reduced sulphur for the biosynthesis of all sulphur-containing metabolites. This process is driven by a sequence of enzymatic steps involving phosphoadenylyl sulphate (PAPS) reductase. Thioredoxin is used as the electron donor for the reduction of PAPS to phospho-adenosine-phosphate (PAP) and sulphite. Unlike most electron-transfer reactions, there are no cofactors or prosthetic groups involved in this reduction and PAPS reductase is one of the rare examples of an enzyme that is able to store two electrons. Determination of the structure of PAPS reductase is the first step towards elucidating the biochemical details of the reduction of PAPS to sulphite.

PubMed: 9261082
DOI: 10.1016/S0969-2126(97)00244-X

実験手法

X-RAY DIFFRACTION (2 Å)