1STY

THE ALPHA ANEURISM: A STRUCTURAL MOTIF REVEALED IN AN INSERTION MUTANT OF STAPHYLOCOCCAL NUCLEASE

1STY の概要

• エントリーDOI: 10.2210/pdb1sty/pdb
• 分子名称: STAPHYLOCOCCAL NUCLEASE, CALCIUM ION, THYMIDINE-3',5'-DIPHOSPHATE, ... (4 entities in total)
• 機能のキーワード: hydrolase (phosphoric diester)
• 由来する生物種: Staphylococcus aureus
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 17342.65

構造登録者

Keefe, L.J.,Lattman, E.E. (登録日: 1993-02-18, 公開日: 1993-04-15, 最終更新日: 2024-02-14)

主引用文献

Keefe, L.J.,Sondek, J.,Shortle, D.,Lattman, E.E.
The alpha aneurism: a structural motif revealed in an insertion mutant of staphylococcal nuclease.
Proc.Natl.Acad.Sci.USA, 90:3275-3279, 1993

PubMed Abstract: The x-ray crystal structure of a mutant of staphylococcal nuclease that contains a single glycine residue inserted in the C-terminal alpha-helix has been solved to 1.67 A resolution and refined to a crystallographic R value of 0.170. This inserted glycine residue is accommodated in the alpha-helix by formation of a previously uncharacterized bulge, which we term the alpha aneurism. A conformational search of known protein structures has identified the alpha aneurism in a number of protein families, including the histocompatibility antigens and hemoglobins.

PubMed: 8475069
DOI: 10.1073/pnas.90.8.3275

実験手法

X-RAY DIFFRACTION (1.67 Å)