1SRO

S1 RNA BINDING DOMAIN, NMR, 20 STRUCTURES

1SRO の概要

• エントリーDOI: 10.2210/pdb1sro/pdb
• 分子名称: PNPASE (1 entity in total)
• 機能のキーワード: s1 rna-binding domain, polynucleotide phosphorylase (pnpase)
• 由来する生物種: Escherichia coli
• 細胞内の位置: Cytoplasm: P05055
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 8380.70

構造登録者

Bycroft, M. (登録日: 1996-11-27, 公開日: 1997-04-01, 最終更新日: 2024-05-22)

主引用文献

Bycroft, M.,Hubbard, T.J.,Proctor, M.,Freund, S.M.,Murzin, A.G.
The solution structure of the S1 RNA binding domain: a member of an ancient nucleic acid-binding fold.
Cell(Cambridge,Mass.), 88:235-242, 1997

PubMed Abstract: The S1 domain, originally identified in ribosomal protein S1, is found in a large number of RNA-associated proteins. The structure of the S1 RNA-binding domain from the E. coli polynucleotide phosphorylase has been determined using NMR methods and consists of a five-stranded antiparallel beta barrel. Conserved residues on one face of the barrel and adjacent loops form the putative RNA-binding site. The structure of the S1 domain is very similar to that of cold shock protein, suggesting that they are both derived from an ancient nucleic acid-binding protein. Enhanced sequence searches reveal hitherto unidentified S1 domains in RNase E, RNase II, NusA, EMB-5, and other proteins.

PubMed: 9008164
DOI: 10.1016/S0092-8674(00)81844-9

実験手法

SOLUTION NMR