1SO8

Abeta-bound human ABAD structure [also known as 3-hydroxyacyl-CoA dehydrogenase type II (Type II HADH), Endoplasmic reticulum-associated amyloid beta-peptide binding protein (ERAB)]

1SO8 の概要

• エントリーDOI: 10.2210/pdb1so8/pdb
• 分子名称: 3-hydroxyacyl-CoA dehydrogenase type II, SODIUM ION, CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: alcohol dehydrogenase; rossmann fold; abeta-induced distorsion, oxidoreductase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Mitochondrion: Q99714
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 27028.45

構造登録者

Lustbader, J.W.,Cirilli, M.,Wu, H. (登録日: 2004-03-13, 公開日: 2004-05-11, 最終更新日: 2024-02-14)

• 主引用文献: Lustbader, J.W.,Cirilli, M.,Lin, C.,Xu, H.W.,Takuma, K.,Wang, N.,Caspersen, C.,Chen, X.,Pollak, S.,Chaney, M.,Trinchese, F.,Gunn-Moore, F.,Lue, L.F.,Walker, D.G.,Kuppusamy, P.,Zewier, Z.L.,Arancio, O.,Stern, D.,Yan, S.S.,Wu, H.; ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease.; Science, 304:448-452, 2004; PubMed: 15087549; DOI: 10.1126/science.1091230

実験手法

X-RAY DIFFRACTION (2.3 Å)