1SO8

Abeta-bound human ABAD structure [also known as 3-hydroxyacyl-CoA dehydrogenase type II (Type II HADH), Endoplasmic reticulum-associated amyloid beta-peptide binding protein (ERAB)]

1SO8 の概要

分子名称3-hydroxyacyl-CoA dehydrogenase type II, SODIUM ION, CHLORIDE ION, ... (4 entities in total)
機能のキーワードalcohol dehydrogenase; rossmann fold; abeta-induced distorsion, oxidoreductase
由来する生物種Homo sapiens (human)
細胞内の位置Mitochondrion Q99714
タンパク質・核酸の鎖数1
分子量合計27028.45
構造登録者
Lustbader, J.W.,Cirilli, M.,Wu, H. (登録日: 2004-03-13, 公開日: 2004-05-11, 最終更新日: 2011-07-13)
主引用文献
Lustbader, J.W.,Cirilli, M.,Lin, C.,Xu, H.W.,Takuma, K.,Wang, N.,Caspersen, C.,Chen, X.,Pollak, S.,Chaney, M.,Trinchese, F.,Gunn-Moore, F.,Lue, L.F.,Walker, D.G.,Kuppusamy, P.,Zewier, Z.L.,Arancio, O.,Stern, D.,Yan, S.S.,Wu, H.
ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease.
Science, 304:448-452, 2004
PubMed: 15087549 (主引用文献が同じPDBエントリー)
DOI: 10.1126/science.1091230
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (2.3 Å)
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構造検証レポート

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.25810 1.5% 2.7% 7.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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件を2020-12-02に公開中