1SKN

THE BINDING DOMAIN OF SKN-1 IN COMPLEX WITH DNA: A NEW DNA-BINDING MOTIF

1SKN の概要

• エントリーDOI: 10.2210/pdb1skn/pdb
• 分子名称: DNA (5'-D(*TP*GP*AP*CP*AP*AP*TP*GP*TP*CP*AP*TP*CP*CP*C)-3'), DNA (5'-D(*CP*AP*GP*GP*GP*AP*TP*GP*AP*CP*AP*TP*TP*GP*T)-3'), DNA-BINDING DOMAIN OF SKN-1, ... (5 entities in total)
• 機能のキーワード: complex (transcription factor-dna), transcription-dna complex, transcription/dna
• 由来する生物種: Caenorhabditis elegans
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 20403.86

構造登録者

Rupert, P.B.,Daughdrill, G.W.,Bowerman, B.,Matthews, B.W. (登録日: 1998-03-30, 公開日: 1998-06-24, 最終更新日: 2024-02-14)

主引用文献

Rupert, P.B.,Daughdrill, G.W.,Bowerman, B.,Matthews, B.W.
A new DNA-binding motif in the Skn-1 binding domain-DNA complex.
Nat.Struct.Biol., 5:484-491, 1998

PubMed Abstract: The DNA-binding domain of Skn-1, a developmental transcription factor that specifies mesoderm in C. elegans, is shown by X-ray crystallography to have a novel fold in which a compact, monomeric, four-helix unit organizes two DNA-contact elements. At the C-terminus, a helix extends from the domain to occupy the major groove of DNA in a manner similar to bZip proteins. Skn-1, however, lacks the leucine zipper found in all bZips. Additional contacts with the DNA are made by a short basic segment at the N-terminus of the domain, reminiscent of the 'homeodomain arm'.

PubMed: 9628487
DOI: 10.1038/nsb0698-484

実験手法

X-RAY DIFFRACTION (2.5 Å)