1SII

AGAO in covalent complex with the inhibitor NOBA ("4-(2-naphthyloxy)-2-butyn-1-amine")

1SII の概要

• エントリーDOI: 10.2210/pdb1sii/pdb
• 関連するPDBエントリー: 1AV4 1SIH
• 分子名称: Phenylethylamine oxidase, COPPER (II) ION, SODIUM ION, ... (6 entities in total)
• 機能のキーワード: cao, cuao, copper-containing, amine oxidase, tpq, quinone, trihydroxyphenylalanine quinone, noba, 4-(2-naphthyloxy)-2-butyn-1-amine, 4-(aryloxy)-2-butynamine, suicide inhibition, oxidoreductase
• 由来する生物種: Arthrobacter globiformis
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 72341.82

構造登録者

Guss, J.M.,Langley, D.B.,Duff, A.P. (登録日: 2004-02-29, 公開日: 2004-09-07, 最終更新日: 2017-10-11)

• 主引用文献: O'Connell, K.M.,Langley, D.B.,Shepard, E.M.,Duff, A.P.,Jeon, H.B.,Sun, G.,Freeman, H.C.,Guss, J.M.,Sayre, L.M.,Dooley, D.M.; Differential Inhibition of Six Copper Amine Oxidases by a Family of 4-(Aryloxy)-2-butynamines: Evidence for a New Mode of Inactivation.; Biochemistry, 43:10965-10978, 2004; PubMed: 15323556; DOI: 10.1021/bi0492004

実験手法

X-RAY DIFFRACTION (1.7 Å)