1SID

MURINE POLYOMAVIRUS COMPLEXED WITH 3'SIALYL LACTOSE

1SID の概要

• エントリーDOI: 10.2210/pdb1sid/pdb
• 分子名称: POLYOMAVIRUS COAT PROTEIN VP1, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-4)-beta-D-glucopyranose (2 entities in total)
• 機能のキーワード: coat protein, icosahedral virus, virus
• 由来する生物種: Mouse polyomavirus (strain p16 small-plaque)
• 細胞内の位置: Virion: P49302
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 258231.97

構造登録者

Stehle, T.,Harrison, S.C. (登録日: 1995-12-12, 公開日: 1996-06-20, 最終更新日: 2024-10-30)

主引用文献

Stehle, T.,Harrison, S.C.
Crystal structures of murine polyomavirus in complex with straight-chain and branched-chain sialyloligosaccharide receptor fragments.
Structure, 4:183-194, 1996

PubMed Abstract: Murine polyomavirus recognizes (alpha2,3)-linked alpha-5-N-acetylneuraminic acid (sialic acid) on the surface of susceptible cells. While all strains bind to straight-chain receptors terminating in (alpha2,3)-linked sialic acid, some strains also bind to branched oligosaccharides that carry a second, (alpha2,6)-linked sialic acid. The ability to bind to these branched-chain receptors correlates with a single amino acid mutation at position 91 on the outer surface of the major capsid protein, VP1, and with a significant decrease in tumorigenicity.

PubMed: 8805524
DOI: 10.1016/S0969-2126(96)00021-4

実験手法

X-RAY DIFFRACTION (3.65 Å)