1SI7

Structure of E. coli tRNA psi 13 pseudouridine synthase TruD

1SI7 の概要

• エントリーDOI: 10.2210/pdb1si7/pdb
• 分子名称: tRNA pseudouridine synthase D (2 entities in total)
• 機能のキーワード: trud, pseudouridine synthase, trna, novel fold, lyase
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 41311.76

構造登録者

Kaya, Y.,Del Campo, M.,Ofengand, J.,Malhotra, A. (登録日: 2004-02-27, 公開日: 2004-03-16, 最終更新日: 2024-04-03)

主引用文献

Kaya, Y.,Del Campo, M.,Ofengand, J.,Malhotra, A.
Crystal structure of TruD, a novel pseudouridine synthase with a new protein fold
J.Biol.Chem., 279:18107-18110, 2004

PubMed Abstract: TruD, a recently discovered novel pseudouridine synthase in Escherichia coli, is responsible for modifying uridine13 in tRNA(Glu) to pseudouridine. It has little sequence homology with the other 10 pseudouridine synthases in E. coli which themselves have been grouped into four related protein families. Crystal structure determination of TruD revealed a two domain structure consisting of a catalytic domain that differs in sequence but is structurally very similar to the catalytic domain of other pseudouridine synthases and a second large domain (149 amino acids, 43% of total) with a novel alpha/beta fold that up to now has not been found in any other protein.

PubMed: 14999002
DOI: 10.1074/jbc.C400072200

実験手法

X-RAY DIFFRACTION (2.2 Å)