1SHJ

Caspase-7 in complex with DICA allosteric inhibitor

Summary for 1SHJ

• Entry DOI: 10.2210/pdb1shj/pdb
• Related: 1SHL
• Descriptor: Caspase-7, SULFATE ION, 2-(2,4-DICHLORO-PHENOXY)-N-(2-MERCAPTO-ETHYL)-ACETAMIDE (3 entities in total)
• Functional Keywords: cysteine protease, allosteric, inhibitor, central cavity, hydrolase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P55210
• Total number of polymer chains: 2
• Total formula weight: 60730.51

Authors

Hardy, J.A.,Lam, J.,Nguyen, J.T.,O'Brien, T.,Wells, J.A. (deposition date: 2004-02-25, release date: 2004-08-17, Last modification date: 2023-08-23)

• Primary citation: Hardy, J.A.,Lam, J.,Nguyen, J.T.,O'Brien, T.,Wells, J.A.; Discovery of an allosteric site in the caspases; Proc.Natl.Acad.Sci.USA, 101:12461-12466, 2004; PubMed: 15314233; DOI: 10.1073/pnas.0404781101

Experimental method

X-RAY DIFFRACTION (2.8 Å)