1SGZ
Crystal Structure of Unbound Beta-Secretase Catalytic Domain.
Summary for 1SGZ
Entry DOI | 10.2210/pdb1sgz/pdb |
Related | 1FKN 1M4H |
Descriptor | Beta-secretase (2 entities in total) |
Functional Keywords | beta-secretase, memapsin, bace, aspartic protease, protease flap, drug design, asp2, alzheimer's disease, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type I membrane protein: P56817 |
Total number of polymer chains | 4 |
Total formula weight | 173251.22 |
Authors | |
Primary citation | Hong, L.,Tang, J. Flap Position of Free Memapsin 2 (beta-Secretase), a Model for Flap Opening in Aspartic Protease Catalysis Biochemistry, 43:4689-4695, 2004 Cited by PubMed: 15096037DOI: 10.1021/bi0498252 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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