Summary for 1SFO
| Entry DOI | 10.2210/pdb1sfo/pdb |
| Related | 1R9S 1R9T |
| Descriptor | RNA STRAND, DNA-directed RNA polymerases I, II, and III 8.3 kDa polypeptide, DNA-directed RNA polymerase II 13.6 kDa polypeptide, ... (14 entities in total) |
| Functional Keywords | transcription, mrna, multiprotein complex, molecular machine, dna, transcription-dna-rna hybrid complex, transcription/dna-rna hybrid |
| Biological source | Saccharomyces cerevisiae (baker's yeast) More |
| Cellular location | Nucleus: P04050 P08518 P16370 P20434 P20436 P27999 P38902 Nucleus, nucleolus: P40422 P22139 Cytoplasm: P20435 |
| Total number of polymer chains | 12 |
| Total formula weight | 477653.35 |
| Authors | Westover, K.D.,Bushnell, D.A.,Kornberg, R.D. (deposition date: 2004-02-20, release date: 2004-03-02, Last modification date: 2024-10-30) |
| Primary citation | Westover, K.D.,Bushnell, D.A.,Kornberg, R.D. Structural Basis of Transcription: Separation of RNA from DNA by RNA Polymerase II Science, 303:1014-1016, 2004 Cited by PubMed Abstract: The structure of an RNA polymerase II-transcribing complex has been determined in the posttranslocation state, with a vacancy at the growing end of the RNA-DNA hybrid helix. At the opposite end of the hybrid helix, the RNA separates from the template DNA. This separation of nucleic acid strands is brought about by interaction with a set of proteins loops in a strand/loop network. Formation of the network must occur in the transition from abortive initiation to promoter escape. PubMed: 14963331DOI: 10.1126/science.1090839 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3.61 Å) |
Structure validation
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