1SFO

RNA POLYMERASE II STRAND SEPARATED ELONGATION COMPLEX

「1R9R」から置き換えられました

1SFO の概要

• エントリーDOI: 10.2210/pdb1sfo/pdb
• 関連するPDBエントリー: 1R9S 1R9T
• 分子名称: RNA STRAND, DNA-directed RNA polymerases I, II, and III 8.3 kDa polypeptide, DNA-directed RNA polymerase II 13.6 kDa polypeptide, ... (14 entities in total)
• 機能のキーワード: transcription, mrna, multiprotein complex, molecular machine, dna, transcription-dna-rna hybrid complex, transcription/dna-rna hybrid
• 由来する生物種: Saccharomyces cerevisiae (baker's yeast); 詳細
• 細胞内の位置: Nucleus: P04050 P08518 P16370 P20434 P20436 P27999 P38902; Nucleus, nucleolus: P40422 P22139; Cytoplasm: P20435
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 477653.35

構造登録者

Westover, K.D.,Bushnell, D.A.,Kornberg, R.D. (登録日: 2004-02-20, 公開日: 2004-03-02, 最終更新日: 2024-10-30)

主引用文献

Westover, K.D.,Bushnell, D.A.,Kornberg, R.D.
Structural Basis of Transcription: Separation of RNA from DNA by RNA Polymerase II
Science, 303:1014-1016, 2004

PubMed Abstract: The structure of an RNA polymerase II-transcribing complex has been determined in the posttranslocation state, with a vacancy at the growing end of the RNA-DNA hybrid helix. At the opposite end of the hybrid helix, the RNA separates from the template DNA. This separation of nucleic acid strands is brought about by interaction with a set of proteins loops in a strand/loop network. Formation of the network must occur in the transition from abortive initiation to promoter escape.

PubMed: 14963331
DOI: 10.1126/science.1090839

実験手法

X-RAY DIFFRACTION (3.61 Å)