1SFK
Core (C) protein from West Nile Virus, subtype Kunjin
Summary for 1SFK
| Entry DOI | 10.2210/pdb1sfk/pdb |
| Descriptor | Core protein, CALCIUM ION, CHLORIDE ION, ... (6 entities in total) |
| Functional Keywords | alpha helix, viral protein |
| Biological source | Kunjin virus |
| Cellular location | Capsid protein C: Virion (Potential). Peptide pr: Secreted (By similarity). Small envelope protein M: Virion membrane; Multi-pass membrane protein (By similarity). Envelope protein E: Virion membrane; Multi- pass membrane protein (By similarity). Non-structural protein 1: Secreted. Non-structural protein 2A: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease subunit NS2B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). RNA-directed RNA polymerase NS5: Host endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (By similarity): P14335 |
| Total number of polymer chains | 8 |
| Total formula weight | 70096.51 |
| Authors | Dokland, T.,Walsh, M.,Mackenzie, J.M.,Khromykh, A.A.,Ee, K.-H.,Wang, S. (deposition date: 2004-02-19, release date: 2004-08-09, Last modification date: 2024-03-13) |
| Primary citation | Dokland, T.,Walsh, M.,Mackenzie, J.M.,Khromykh, A.A.,Ee, K.-H.,Wang, S. West nile virus core protein; tetramer structure and ribbon formation Structure, 12:1157-1163, 2004 Cited by PubMed Abstract: We have determined the crystal structure of the core (C) protein from the Kunjin subtype of West Nile virus (WNV), closely related to the NY99 strain of WNV, currently a major health threat in the U.S. WNV is a member of the Flaviviridae family of enveloped RNA viruses that contains many important human pathogens. The C protein is associated with the RNA genome and forms the internal core which is surrounded by the envelope in the virion. The C protein structure contains four alpha helices and forms dimers that are organized into tetramers. The tetramers form extended filamentous ribbons resembling the stacked alpha helices seen in HEAT protein structures. PubMed: 15242592DOI: 10.1016/j.str.2004.04.024 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3.2 Å) |
Structure validation
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