1SEK

THE STRUCTURE OF ACTIVE SERPIN K FROM MANDUCA SEXTA AND A MODEL FOR SERPIN-PROTEASE COMPLEX FORMATION

1SEK の概要

• エントリーDOI: 10.2210/pdb1sek/pdb
• 分子名称: SERPIN K (2 entities in total)
• 機能のキーワード: serine protease inhibitor, serpin, protease
• 由来する生物種: Manduca sexta (tobacco hornworm)
• 細胞内の位置: Secreted, extracellular space: P14754
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 42273.17

構造登録者

Li, J.,Wang, Z.,Canagarajah, B.,Jiang, H.,Kanost, M.,Goldsmith, E.J. (登録日: 1998-03-06, 公開日: 1999-03-23, 最終更新日: 2024-02-14)

主引用文献

Li, J.,Wang, Z.,Canagarajah, B.,Jiang, H.,Kanost, M.,Goldsmith, E.J.
The structure of active serpin 1K from Manduca sexta.
Structure Fold.Des., 7:103-109, 1999

PubMed Abstract: The reactive center loops (RCL) of serpins undergo large conformational changes triggered by the interaction with their target protease. Available crystallographic data suggest that the serpin RCL is polymorphic, but the relevance of the observed conformations to the competent active structure and the conformational changes that occur on binding target protease has remained obscure. New high-resolution data on an active serpin, serpin 1K from the moth hornworm Manduca sexta, provide insights into how active serpins are stabilized and how conformational changes are induced by protease binding.

PubMed: 10368276
DOI: 10.1016/S0969-2126(99)80013-6

実験手法

X-RAY DIFFRACTION (2.1 Å)