1SDV

Crystal structures of HIV protease V82A and L90M mutants reveal changes in indinavir binding site.

1SDV の概要

• エントリーDOI: 10.2210/pdb1sdv/pdb
• 関連するPDBエントリー: 1FF0 1SDT 1SDU
• 分子名称: protease RETROPEPSIN, CHLORIDE ION, N-[2(R)-HYDROXY-1(S)-INDANYL]-5-[(2(S)-TERTIARY BUTYLAMINOCARBONYL)-4(3-PYRIDYLMETHYL)PIPERAZINO]-4(S)-HYDROXY-2(R)-PHENYLMETHYLPENTANAMIDE, ... (4 entities in total)
• 機能のキーワード: drug resistance; hiv-1 protease, hydrolase
• 由来する生物種: Human immunodeficiency virus 1
• 細胞内の位置: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03367
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22109.94

構造登録者

Mahalingam, B.,Wang, Y.-F.,Boross, P.I.,Tozser, J.,Louis, J.M.,Harrison, R.W.,Weber, I.T. (登録日: 2004-02-14, 公開日: 2004-05-25, 最終更新日: 2023-08-23)

• 主引用文献: Mahalingam, B.,Wang, Y.-F.,Boross, P.I.,Tozser, J.,Louis, J.M.,Harrison, R.W.,Weber, I.T.; Crystal structures of HIV protease V82A and L90M mutants reveal changes in the indinavir-binding site; Eur.J.Biochem., 271:1516-1524, 2004; PubMed: 15066177; DOI: 10.1111/j.1432-1033.2004.04060.x

実験手法

X-RAY DIFFRACTION (1.4 Å)