1SD2

STRUCTURE OF HUMAN 5'-DEOXY-5'-METHYLTHIOADENOSINE PHOSPHORYLASE COMPLEXED WITH 5'-METHYLTHIOTUBERCIDIN

Summary for 1SD2

Entry DOI	10.2210/pdb1sd2/pdb
Descriptor	5'-methylthioadenosine phosphorylase, SULFATE ION, 2-(4-AMINO-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-METHYLSULFANYLMETHYL-TETRAHYDRO-FURAN-3,4-DIOL, ... (4 entities in total)
Functional Keywords	methylthioadenosine phosphorylase, purine nucleoside phosphorylase, purine salvage, 5'-methylthiotubercidin, mtt, sulfate, transferase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: Q13126
Total number of polymer chains	1
Total formula weight	31669.46
Authors	Lee, J.E.,Settembre, E.C.,Cornell, K.A.,Riscoe, M.K.,Sufrin, J.R.,Ealick, S.E.,Howell, P.L. (deposition date: 2004-02-12, release date: 2004-05-18, Last modification date: 2024-02-14)
Primary citation	Lee, J.E.,Settembre, E.C.,Cornell, K.A.,Riscoe, M.K.,Sufrin, J.R.,Ealick, S.E.,Howell, P.L. Structural Comparison of MTA Phosphorylase and MTA/AdoHcy Nucleosidase Explains Substrate Preferences and Identifies Regions Exploitable for Inhibitor Design. Biochemistry, 43:5159-5169, 2004 Cited by PubMed: 15122881 DOI: 10.1021/bi035492h PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation