1SD1

STRUCTURE OF HUMAN 5'-DEOXY-5'-METHYLTHIOADENOSINE PHOSPHORYLASE COMPLEXED WITH FORMYCIN A

1SD1 の概要

• エントリーDOI: 10.2210/pdb1sd1/pdb
• 分子名称: 5'-methylthioadenosine phosphorylase, (1S)-1-(7-amino-1H-pyrazolo[4,3-d]pyrimidin-3-yl)-1,4-anhydro-D-ribitol (3 entities in total)
• 機能のキーワード: methylthioadenosine phosphorylase, purine nucleoside phosphorylase, purine salvage, formycin a, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: Q13126
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 31544.29

構造登録者

Lee, J.E.,Settembre, E.C.,Cornell, K.A.,Riscoe, M.K.,Sufrin, J.R.,Ealick, S.E.,Howell, P.L. (登録日: 2004-02-12, 公開日: 2004-05-18, 最終更新日: 2024-02-14)

• 主引用文献: Lee, J.E.,Settembre, E.C.,Cornell, K.A.,Riscoe, M.K.,Sufrin, J.R.,Ealick, S.E.,Howell, P.L.; Structural Comparison of MTA Phosphorylase and MTA/AdoHcy Nucleosidase Explains Substrate Preferences and Identifies Regions Exploitable for Inhibitor Design.; Biochemistry, 43:5159-5169, 2004; PubMed: 15122881; DOI: 10.1021/bi035492h

実験手法

X-RAY DIFFRACTION (2.03 Å)