X-ray Crystal Structure of a Complex Formed Between Two Homologous Isoforms of Phospholipase A2 from Naja naja sagittifera: Principle of Molecular Association and Inactivation

Replaces:  1LFJ

Summary for 1S6B

DescriptorPhospholipase A2 isoform 1, Phospholipase A2 isoform 2, CALCIUM ION, ... (6 entities in total)
Functional Keywordsphospholipase a2, molecular conformation, enzyme activity, hydrolase
Biological sourceNaja sagittifera
Cellular locationSecreted P60043 P60044
Total number of polymer chains2
Total molecular weight26899.57
Jabeen, T.,Sharma, S.,Singh, R.K.,Kaur, P.,Singh, T.P. (deposition date: 2004-01-23, release date: 2004-02-10, Last modification date: 2018-02-07)
Primary citation
Jabeen, T.,Sharma, S.,Singh, N.,Singh, R.K.,Kaur, P.,Perbandt, M.,Betzel, C.h.,Srinivasan, A.,Singh, T.P.
Crystal structure of a calcium-induced dimer of two isoforms of cobra phospholipase A2 at 1.6 A resolution.
Proteins, 59:856-863, 2005
PubMed: 15828003 (PDB entries with the same primary citation)
DOI: 10.1002/prot.20464
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliers804.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution