1S5I

Fab (LNKB-2) of monoclonal antibody to Human Interleukin-2, crystal structure

1S5I の概要

• エントリーDOI: 10.2210/pdb1s5i/pdb
• 関連するPDBエントリー: 1F8T 1F90
• 分子名称: Fab-fragment of monoclonal antibody (3 entities in total)
• 機能のキーワード: monoclonal antibody, antigen-binding fragment, interleukin-2, x-ray analysis, immune system
• 由来する生物種: Mus musculus (house mouse); 詳細
• 細胞内の位置: Cell membrane ; Single-pass membrane protein : P01869
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 48073.51

構造登録者

Pletnev, V.Z.,Goryacheva, E.A.,Tsygannik, I.N.,Nesmeyanov, V.A.,Pletnev, S.V.,Pangborn, W.,Duax, W. (登録日: 2004-01-21, 公開日: 2004-05-25, 最終更新日: 2024-10-30)

主引用文献

Pletnev, V.Z.,Goriacheva, E.A.,Tsygannik, I.N.,Nesmeianov, V.A.,Pletnev, S.V.,Pangborn, W.,Daux, W.
[A new crystal form of the Fab fragment of a monoclonal antibody to human interleukin-2: the three-dimensional structure at 2.7 A resolution].
Bioorg. Khim., 30:466-469,

PubMed Abstract: The three-dimensional structure of the antigen-binding fragment of a monoclonal antibody to human interleukin-2 in a new crystal form (space group P2(1)2(1)2(1); unit cell parameters: a = 42.82, b = 90.68, and c = 139.82 A) was determined by the X-ray molecular replacement method at the resolution of 2.7 A. The protein folding and the stereochemistry of its antigen-binding site were comparatively analyzed. The English version of the paper: Russian Journal of Bioorganic Chemistry, 2004, vol. 30, no. 5; see also http: // www.maik.ru.

PubMed: 15562966

実験手法

X-RAY DIFFRACTION (2.7 Å)