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1S3Y

Structure Determination of Tetrahydroquinazoline Antifolates in Complex with Human and Pneumocystis carinii Dihydrofolate Reductase: Correlations of Enzyme Selectivity and Stereochemistry

Summary for 1S3Y
Entry DOI10.2210/pdb1s3y/pdb
DescriptorDihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 6-(OCTAHYDRO-1H-INDOL-1-YLMETHYL)DECAHYDROQUINAZOLINE-2,4-DIAMINE, ... (4 entities in total)
Functional Keywordspneumocystis carinii dihydrofolate reductase, inhibitors, stereochemistry, oxidoreductase
Biological sourcePneumocystis carinii
Total number of polymer chains1
Total formula weight24969.42
Authors
Cody, V.,Luft, J.R.,Pangborn, W.,Gangjee, A.,Queener, S.F. (deposition date: 2004-01-14, release date: 2004-03-30, Last modification date: 2024-02-14)
Primary citationCody, V.,Luft, J.R.,Pangborn, W.,Gangjee, A.,Queener, S.F.
Structure determination of tetrahydroquinazoline antifolates in complex with human and Pneumocystis carinii dihydrofolate reductase: correlations between enzyme selectivity and stereochemistry.
Acta Crystallogr.,Sect.D, 60:646-655, 2004
Cited by
PubMed: 15039552
DOI: 10.1107/S0907444904002094
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.25 Å)
Structure validation

217705

数据于2024-03-27公开中

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