1S3Y

Structure Determination of Tetrahydroquinazoline Antifolates in Complex with Human and Pneumocystis carinii Dihydrofolate Reductase: Correlations of Enzyme Selectivity and Stereochemistry

1S3Y の概要

• エントリーDOI: 10.2210/pdb1s3y/pdb
• 分子名称: Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 6-(OCTAHYDRO-1H-INDOL-1-YLMETHYL)DECAHYDROQUINAZOLINE-2,4-DIAMINE, ... (4 entities in total)
• 機能のキーワード: pneumocystis carinii dihydrofolate reductase, inhibitors, stereochemistry, oxidoreductase
• 由来する生物種: Pneumocystis carinii
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 24969.42

構造登録者

Cody, V.,Luft, J.R.,Pangborn, W.,Gangjee, A.,Queener, S.F. (登録日: 2004-01-14, 公開日: 2004-03-30, 最終更新日: 2024-02-14)

• 主引用文献: Cody, V.,Luft, J.R.,Pangborn, W.,Gangjee, A.,Queener, S.F.; Structure determination of tetrahydroquinazoline antifolates in complex with human and Pneumocystis carinii dihydrofolate reductase: correlations between enzyme selectivity and stereochemistry.; Acta Crystallogr.,Sect.D, 60:646-655, 2004; PubMed: 15039552; DOI: 10.1107/S0907444904002094

実験手法

X-RAY DIFFRACTION (2.25 Å)