1S3Y
Structure Determination of Tetrahydroquinazoline Antifolates in Complex with Human and Pneumocystis carinii Dihydrofolate Reductase: Correlations of Enzyme Selectivity and Stereochemistry
1S3Y の概要
エントリーDOI | 10.2210/pdb1s3y/pdb |
分子名称 | Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 6-(OCTAHYDRO-1H-INDOL-1-YLMETHYL)DECAHYDROQUINAZOLINE-2,4-DIAMINE, ... (4 entities in total) |
機能のキーワード | pneumocystis carinii dihydrofolate reductase, inhibitors, stereochemistry, oxidoreductase |
由来する生物種 | Pneumocystis carinii |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 24969.42 |
構造登録者 | Cody, V.,Luft, J.R.,Pangborn, W.,Gangjee, A.,Queener, S.F. (登録日: 2004-01-14, 公開日: 2004-03-30, 最終更新日: 2024-02-14) |
主引用文献 | Cody, V.,Luft, J.R.,Pangborn, W.,Gangjee, A.,Queener, S.F. Structure determination of tetrahydroquinazoline antifolates in complex with human and Pneumocystis carinii dihydrofolate reductase: correlations between enzyme selectivity and stereochemistry. Acta Crystallogr.,Sect.D, 60:646-655, 2004 Cited by PubMed: 15039552DOI: 10.1107/S0907444904002094 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.25 Å) |
構造検証レポート
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