1S2E

BACTERIOPHAGE T4 GENE PRODUCT 9 (GP9), THE TRIGGER OF TAIL CONTRACTION AND THE LONG TAIL FIBERS CONNECTOR, ALTERNATIVE FIT OF THE FIRST 19 RESIDUES

Summary for 1S2E

• Entry DOI: 10.2210/pdb1s2e/pdb
• Related: 1QEX
• Descriptor: Baseplate structural protein Gp9, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID (3 entities in total)
• Functional Keywords: bacteriophage t4, baseplate, gene product 9, oligomerization, virus/viral protein, viral protein
• Biological source: Enterobacteria phage T4
• Cellular location: Virion : P10927
• Total number of polymer chains: 2
• Total formula weight: 62526.06

Authors

Kostyuchenko, V.A.,Navruzbekov, G.A.,Kurochkina, L.P.,Strelkov, S.V.,Mesyanzhinov, V.V.,Rossmann, M.G. (deposition date: 2004-01-08, release date: 2004-01-13, Last modification date: 2024-02-14)

Primary citation

Kostyuchenko, V.A.,Navruzbekov, G.A.,Kurochkina, L.P.,Strelkov, S.V.,Mesyanzhinov, V.V.,Rossmann, M.G.
The Structure of Bacteriophage T4 Gene Product 9: The Trigger for Tail Contraction
Structure Fold.Des., 7:1213-1222, 1999

PubMed Abstract: The T4 bacteriophage consists of a head, filled with double-stranded DNA, and a complex contractile tail required for the ejection of the viral genome into the Escherichia coli host. The tail has a baseplate to whïch are attached six long and six short tail fibers. These fibers are the sensing devices for recognizing the host. When activated by attachment to cell receptors, the fibers cause a conformational transition in the baseplate and subsequently in the tail sheath, which initiates DNA ejection. The baseplate is a multisubunit complex of proteins encoded by 15 genes. Gene product 9 (gp9) is the protein that connects the long tail fibers to the baseplate and triggers the tail contraction after virus attachment to a host cell.

PubMed: 10545330
DOI: 10.1016/S0969-2126(00)80055-6

Experimental method

X-RAY DIFFRACTION (2.3 Å)