1S2E

BACTERIOPHAGE T4 GENE PRODUCT 9 (GP9), THE TRIGGER OF TAIL CONTRACTION AND THE LONG TAIL FIBERS CONNECTOR, ALTERNATIVE FIT OF THE FIRST 19 RESIDUES

1S2E の概要

• エントリーDOI: 10.2210/pdb1s2e/pdb
• 関連するPDBエントリー: 1QEX
• 分子名称: Baseplate structural protein Gp9, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID (3 entities in total)
• 機能のキーワード: bacteriophage t4, baseplate, gene product 9, oligomerization, virus/viral protein, viral protein
• 由来する生物種: Enterobacteria phage T4
• 細胞内の位置: Virion : P10927
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 62526.06

構造登録者

Kostyuchenko, V.A.,Navruzbekov, G.A.,Kurochkina, L.P.,Strelkov, S.V.,Mesyanzhinov, V.V.,Rossmann, M.G. (登録日: 2004-01-08, 公開日: 2004-01-13, 最終更新日: 2024-02-14)

主引用文献

Kostyuchenko, V.A.,Navruzbekov, G.A.,Kurochkina, L.P.,Strelkov, S.V.,Mesyanzhinov, V.V.,Rossmann, M.G.
The Structure of Bacteriophage T4 Gene Product 9: The Trigger for Tail Contraction
Structure Fold.Des., 7:1213-1222, 1999

PubMed Abstract: The T4 bacteriophage consists of a head, filled with double-stranded DNA, and a complex contractile tail required for the ejection of the viral genome into the Escherichia coli host. The tail has a baseplate to whïch are attached six long and six short tail fibers. These fibers are the sensing devices for recognizing the host. When activated by attachment to cell receptors, the fibers cause a conformational transition in the baseplate and subsequently in the tail sheath, which initiates DNA ejection. The baseplate is a multisubunit complex of proteins encoded by 15 genes. Gene product 9 (gp9) is the protein that connects the long tail fibers to the baseplate and triggers the tail contraction after virus attachment to a host cell.

PubMed: 10545330
DOI: 10.1016/S0969-2126(00)80055-6

実験手法

X-RAY DIFFRACTION (2.3 Å)