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1S0Z

Crystal structure of the VDR LBD complexed to seocalcitol.

Summary for 1S0Z
Entry DOI10.2210/pdb1s0z/pdb
Related1DB1 1IE8 1IE9 1S19
DescriptorVitamin D3 receptor, SEOCALCITOL (3 entities in total)
Functional Keywordsnuclear receptor, transcription regulation, alpha-helical sandwich, gene regulation
Biological sourceHomo sapiens (human)
More
Cellular locationNucleus: P11473
Total number of polymer chains1
Total formula weight30260.03
Authors
Tocchini-Valentini, G.,Rochel, N.,Wurtz, J.M.,Moras, D. (deposition date: 2004-01-05, release date: 2004-04-13, Last modification date: 2024-02-14)
Primary citationTocchini-Valentini, G.,Rochel, N.,Wurtz, J.M.,Moras, D.
Crystal structures of the vitamin D nuclear receptor liganded with the vitamin D side chain analogues calcipotriol and seocalcitol, receptor agonists of clinical importance. Insights into a structural basis for the switching of calcipotriol to a receptor antagonist by further side chain modification.
J.Med.Chem., 47:1956-1961, 2004
Cited by
PubMed: 15055995
DOI: 10.1021/jm0310582
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.5 Å)
Structure validation

217705

數據於2024-03-27公開中

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