1S0Y

The structure of trans-3-chloroacrylic acid dehalogenase, covalently inactivated by the mechanism-based inhibitor 3-bromopropiolate at 2.3 Angstrom resolution

1S0Y の概要

• エントリーDOI: 10.2210/pdb1s0y/pdb
• 分子名称: alpha-subunit of trans-3-chloroacrylic acid dehalogenase, beta-subunit of trans-3-chloroacrylic acid dehalogenase, MALONIC ACID, ... (4 entities in total)
• 機能のキーワード: dehalogenase, tautomerase family, covalent modification, inhibition, michael addition, dehalogenation mechanism, malonyl inhibitor, lyase
• 由来する生物種: Pseudomonas pavonaceae; 詳細
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 97431.17

構造登録者

de Jong, R.M.,Brugman, W.,Poelarends, G.J.,Whitman, C.P.,Dijkstra, B.W. (登録日: 2004-01-05, 公開日: 2004-02-24, 最終更新日: 2023-08-23)

• 主引用文献: de Jong, R.M.,Brugman, W.,Poelarends, G.J.,Whitman, C.P.,Dijkstra, B.W.; The X-ray structure of trans-3-chloroacrylic acid dehalogenase reveals a novel hydration mechanism in the tautomerase superfamily; J.Biol.Chem., 279:11546-11552, 2004; PubMed: 14701869; DOI: 10.1074/jbc.M311966200

実験手法

X-RAY DIFFRACTION (2.3 Å)