1RXL

Solution structure of the engineered protein Afae-dsc

1RXL の概要

• エントリーDOI: 10.2210/pdb1rxl/pdb
• 関連するPDBエントリー: 1SDD 1USQ 1USZ 1UT1 1UT2
• NMR情報: BMRB: 5947
• 分子名称: Afimbrial adhesin AFA-III (1 entity in total)
• 機能のキーワード: afae, daf, afimbrial sheath, daec, upec, ig-like domain, donor strand complemented, structural protein
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 16952.71

構造登録者

Anderson, K.L.,Billington, J.,Pettigrew, D.,Cota, E.,Roversi, P.,Simpson, P.,Chen, H.A.,Urvil, P.,du Merle, L.,Barlow, P.N.,Medof, M.E.,Smith, R.A.,Nowicki, B.,Le Bouguenec, C.,Lea, S.M.,Matthews, S. (登録日: 2003-12-18, 公開日: 2005-01-11, 最終更新日: 2024-11-06)

主引用文献

Anderson, K.L.,Billington, J.,Pettigrew, D.,Cota, E.,Simpson, P.,Roversi, P.,Chen, H.A.,Urvil, P.,du Merle, L.,Barlow, P.N.,Medof, M.E.,Smith, R.A.,Nowicki, B.,Le Bouguenec, C.,Lea, S.M.,Matthews, S.
An atomic resolution model for assembly, architecture, and function of the Dr adhesins.
Mol.Cell, 15:647-657, 2004

PubMed Abstract: Pathogenic bacteria possess adhesion protein complexes that play essential roles in targeting host cells and in propagating infection. Although each family of adhesion proteins is generally associated with a specific human disease, the Dr family from Escherichia coli is a notable exception, as its members are associated with both diarrheal and urinary tract infections. These proteins are reported to form both fimbrial and afimbrial structures at the bacterial cell surface and target a common host cell receptor, the decay-accelerating factor (DAF or CD55). Using the newly solved three-dimensional structure of AfaE, we have constructed a robust atomic resolution model that reveals the structural basis for assembly by donor strand complementation and for the architecture of capped surface fibers.

PubMed: 15327779
DOI: 10.1016/j.molcel.2004.08.003

実験手法

SOLUTION NMR