1RUZ

1918 H1 Hemagglutinin

1RUZ の概要

• エントリーDOI: 10.2210/pdb1ruz/pdb
• 関連するPDBエントリー: 1RU7 1RUY 1RV0 1RVT 1RVX 1RVZ
• 分子名称: hemagglutinin, 2-acetamido-2-deoxy-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• 機能のキーワード: hemagglutinin, influenza a virus, viral protein
• 由来する生物種: Influenza A virus (A/South Carolina/1/18 (H1N1)); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 165445.96

構造登録者

Skehel, J.J.,Gamblin, S.J.,Haire, L.F.,Russell, R.J.,Stevens, D.J.,Xiao, B.,Ha, Y.,Vasisht, N.,Steinhauer, D.A.,Daniels, R.S. (登録日: 2003-12-12, 公開日: 2004-03-30, 最終更新日: 2024-10-30)

主引用文献

Gamblin, S.J.,Haire, L.F.,Russell, R.J.,Stevens, D.J.,Xiao, B.,Ha, Y.,Vasisht, N.,Steinhauer, D.A.,Daniels, R.S.,Elliot, A.,Wiley, D.C.,Skehel, J.J.
The structure and receptor binding properties of the 1918 influenza hemagglutinin.
Science, 303:1838-1842, 2004

PubMed Abstract: The 1918 influenza pandemic resulted in about 20 million deaths. This enormous impact, coupled with renewed interest in emerging infections, makes characterization of the virus involved a priority. Receptor binding, the initial event in virus infection, is a major determinant of virus transmissibility that, for influenza viruses, is mediated by the hemagglutinin (HA) membrane glycoprotein. We have determined the crystal structures of the HA from the 1918 virus and two closely related HAs in complex with receptor analogs. They explain how the 1918 HA, while retaining receptor binding site amino acids characteristic of an avian precursor HA, is able to bind human receptors and how, as a consequence, the virus was able to spread in the human population.

PubMed: 14764886
DOI: 10.1126/science.1093155

実験手法

X-RAY DIFFRACTION (2.9 Å)