1RTS

THYMIDYLATE SYNTHASE FROM RAT IN TERNARY COMPLEX WITH DUMP AND TOMUDEX

1RTS の概要

• エントリーDOI: 10.2210/pdb1rts/pdb
• 分子名称: THYMIDYLATE SYNTHASE, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, TOMUDEX (3 entities in total)
• 機能のキーワード: thymidylate synthase, methyltransferase, dump, tomudex, antifolate
• 由来する生物種: Rattus norvegicus (Norway rat)
• 細胞内の位置: Nucleus (By similarity): P45352
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 71653.39

構造登録者

Sotelo-Mundo, R.R.,Ciesla, J.,Dzik, J.M.,Rode, W.,Maley, F.,Maley, G.,Hardy, L.W.,Montfort, W.R. (登録日: 1998-06-19, 公開日: 1999-02-16, 最終更新日: 2024-02-14)

• 主引用文献: Sotelo-Mundo, R.R.,Ciesla, J.,Dzik, J.M.,Rode, W.,Maley, F.,Maley, G.F.,Hardy, L.W.,Montfort, W.R.; Crystal structures of rat thymidylate synthase inhibited by Tomudex, a potent anticancer drug.; Biochemistry, 38:1087-1094, 1999; PubMed: 9894005; DOI: 10.1021/bi981881d

実験手法

X-RAY DIFFRACTION (3.3 Å)