1RSY

STRUCTURE OF THE FIRST C2-DOMAIN OF SYNAPTOTAGMIN I: A NOVEL CA2+(SLASH)PHOSPHOLIPID BINDING FOLD

1RSY の概要

• エントリーDOI: 10.2210/pdb1rsy/pdb
• 分子名称: SYNAPTOTAGMIN I, SULFATE ION (3 entities in total)
• 機能のキーワード: calcium/phospholipid binding protein, calcium-phospholipid binding protein complex
• 由来する生物種: Rattus norvegicus (Norway rat)
• 細胞内の位置: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein: P21707
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 17194.41

構造登録者

Sutton, R.B.,Sprang, S.R. (登録日: 1995-02-01, 公開日: 1995-05-08, 最終更新日: 2024-02-14)

主引用文献

Sutton, R.B.,Davletov, B.A.,Berghuis, A.M.,Sudhof, T.C.,Sprang, S.R.
Structure of the first C2 domain of synaptotagmin I: a novel Ca2+/phospholipid-binding fold.
Cell(Cambridge,Mass.), 80:929-938, 1995

PubMed Abstract: C2 domains are regulatory sequence motifs that occur widely in nature. Synaptotagmin I, a synaptic vesicle protein involved in the Ca2+ regulation of exocytosis, contains two C2 domains, the first of which acts as a Ca2+ sensor. We now describe the three-dimensional structure of this C2 domain at 1.9 A resolution in both the Ca(2+)-bound and Ca(2+)-free forms. The C2 polypeptide forms an eight-stranded beta sandwich constructed around a conserved four-stranded motif designated as a C2 key. Ca2+ binds in a cup-shaped depression between two polypeptide loops located at the N- and C-termini of the C2-key motif.

PubMed: 7697723
DOI: 10.1016/0092-8674(95)90296-1

実験手法

X-RAY DIFFRACTION (1.9 Å)