1RQJ
Active Conformation of Farnesyl Pyrophosphate Synthase Bound to Isopentyl Pyrophosphate and Risedronate
Summary for 1RQJ
Entry DOI | 10.2210/pdb1rqj/pdb |
Related | 1RQI 1RTR |
Descriptor | Geranyltranstransferase, MAGNESIUM ION, 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, ... (5 entities in total) |
Functional Keywords | bisphosphonate, isoprenyl synthase, transferase |
Biological source | Escherichia coli |
Cellular location | Cytoplasm: P22939 |
Total number of polymer chains | 2 |
Total formula weight | 65599.47 |
Authors | Hosfield, D.J.,Zhang, Y.,Dougan, D.R.,Brooun, A.,Tari, L.W.,Swanson, R.V.,Finn, J. (deposition date: 2003-12-05, release date: 2004-03-02, Last modification date: 2024-02-14) |
Primary citation | Hosfield, D.J.,Zhang, Y.,Dougan, D.R.,Brooun, A.,Tari, L.W.,Swanson, R.V.,Finn, J. Structural basis for bisphosphonate-mediated inhibition of isoprenoid biosynthesis J.Biol.Chem., 279:8526-8529, 2004 Cited by PubMed: 14672944DOI: 10.1074/jbc.C300511200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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