1RQ9

Crystal structures of a Multidrug-Resistant HIV-1 Protease Reveal an Expanded Active Site Cavity

Summary for 1RQ9

• Entry DOI: 10.2210/pdb1rq9/pdb
• Related: 1rpi 1rv7
• Descriptor: protease, [4-R-(-4-ALPHA,5-ALPHA,6-BETA,7-BETA)]-HEXAHYDRO-5,6-BIS(HYDROXY)-1,3-BIS([(3-AMINO)PHENYL]METHYL)-4,7-BIS(PHENYLMETHYL)-2H-1,3-DIAZEPINONE (3 entities in total)
• Functional Keywords: hiv protease, aids, polyprotein, hydrolase, aspartyl protease, multi-drug resistance
• Biological source: Human immunodeficiency virus 1
• Total number of polymer chains: 2
• Total formula weight: 22015.88

Authors

Logsdon, B.C.,Vickrey, J.F.,Martin, P.,Proteasa, G.,Koepke, J.I.,Terlecky, S.R.,Wawrzak, Z.,Winters, M.A.,Merigan, T.C.,Kovari, L.C. (deposition date: 2003-12-04, release date: 2004-12-07, Last modification date: 2024-04-03)

• Primary citation: Logsdon, B.C.,Vickrey, J.F.,Martin, P.,Proteasa, G.,Koepke, J.I.,Terlecky, S.R.,Wawrzak, Z.,Winters, M.A.,Merigan, T.C.,Kovari, L.C.; Crystal structures of a multidrug-resistant human immunodeficiency virus type 1 protease reveal an expanded active-site cavity.; J.Virol., 78:3123-3132, 2004; PubMed: 14990731; DOI: 10.1128/JVI.78.6.3123-3132.2004

Experimental method

X-RAY DIFFRACTION (2.6 Å)