1RLR

STRUCTURE OF RIBONUCLEOTIDE REDUCTASE PROTEIN R1

1RLR の概要

• エントリーDOI: 10.2210/pdb1rlr/pdb
• 分子名称: RIBONUCLEOTIDE REDUCTASE PROTEIN R1 (1 entity in total)
• 機能のキーワード: reductase (acting on ch2), oxidoreductase
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 86010.27

構造登録者

Uhlin, U.,Eklund, H. (登録日: 1994-08-12, 公開日: 1996-12-23, 最終更新日: 2024-11-20)

主引用文献

Uhlin, U.,Eklund, H.
Structure of ribonucleotide reductase protein R1.
Nature, 370:533-539, 1994

PubMed Abstract: Ribonucleotide reductase is the only enzyme that catalyses de novo formation of deoxyribonucleotides and is thus a key enzyme in DNA synthesis. The radical-based reaction involves five cysteins. Two redox-active cysteines are located at adjacent antiparallel strands in a new type of ten-stranded alpha/beta-barrel, and two others at the carboxyl end in a flexible arm. The fifth cysteine, in a loop in the centre of the barrel, is positioned to initiate the radical reaction.

PubMed: 8052308
DOI: 10.1038/370533a0

実験手法

X-RAY DIFFRACTION (2.5 Å)