1RLB

RETINOL BINDING PROTEIN COMPLEXED WITH TRANSTHYRETIN

1RLB の概要

• エントリーDOI: 10.2210/pdb1rlb/pdb
• 分子名称: TRANSTHYRETIN, RETINOL BINDING PROTEIN, RETINOIC ACID (3 entities in total)
• 機能のキーワード: complex (protein-protein), complex (protein-protein) complex, complex (protein/protein)
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted: P02766 P02753
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 95865.46

構造登録者

Monaco, H.L.,Rizzi, M.,Coda, A. (登録日: 1995-02-20, 公開日: 1996-04-11, 最終更新日: 2024-10-16)

主引用文献

Monaco, H.L.,Rizzi, M.,Coda, A.
Structure of a complex of two plasma proteins: transthyretin and retinol-binding protein.
Science, 268:1039-1041, 1995

PubMed Abstract: The three-dimensional structure of the complex formed by two plasma proteins, transthyretin and retinol-binding protein, was determined from x-ray diffraction data to a nominal resolution of 3.1 angstroms. One tetramer of transthyretin was bound to two molecules of retinol-binding protein. The two retinol-binding protein molecules established molecular interactions with the same transthyretin dimer, and each also made contacts with one of the other two monomers. Thus, the other two potential binding sites in a transthyretin tetramer were blocked. The amino acid residues of the retinol-binding protein that were involved in the contacts were close to the retinol-binding site.

PubMed: 7754382

実験手法

X-RAY DIFFRACTION (3.1 Å)