1RKB
The structure of adrenal gland protein AD-004
Summary for 1RKB
| Entry DOI | 10.2210/pdb1rkb/pdb |
| Descriptor | Protein AD-004, SULFATE ION, LITHIUM ION, ... (4 entities in total) |
| Functional Keywords | five-stranded parallel beta-sheet flanked by 7 alpha-helices, transferase |
| Biological source | Homo sapiens (human) |
| Cellular location | Nucleus, nucleoplasm: Q9Y3D8 |
| Total number of polymer chains | 1 |
| Total formula weight | 20696.70 |
| Authors | Ren, H.,Liang, Y.,Bennett, M.,Su, X.D. (deposition date: 2003-11-21, release date: 2005-01-11, Last modification date: 2024-03-13) |
| Primary citation | Ren, H.,Wang, L.,Bennett, M.,Liang, Y.,Zheng, X.,Lu, F.,Li, L.,Nan, J.,Luo, M.,Eriksson, S.,Zhang, C.,Su, X.D. The crystal structure of human adenylate kinase 6: An adenylate kinase localized to the cell nucleus Proc.Natl.Acad.Sci.Usa, 102:303-308, 2005 Cited by PubMed Abstract: Adenylate kinases (AKs) play important roles in nucleotide metabolism in all organisms and in cellular energetics by means of phosphotransfer networks in eukaryotes. The crystal structure of a human AK named AK6 was determined by in-house sulfur single-wavelength anomalous dispersion phasing methods and refined to 2.0-A resolution with a free R factor of 21.8%. Sequence analyses revealed that human AK6 belongs to a distinct subfamily of AKs present in all eukaryotic organisms sequenced so far. Enzymatic assays show that human AK6 has properties similar with other AKs, particularly with AK5. Fluorescence microscopy showed that human AK6 is localized predominantly to the nucleus of HeLa cells. The identification of a nuclear-localized AK sheds light on nucleotide metabolism in the nucleus and the energetic communication between mitochondria and nucleus by means of phosphotransfer networks. PubMed: 15630091DOI: 10.1073/pnas.0407459102 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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