1RIW

Thrombin in complex with natural product inhibitor Oscillarin

1RIW の概要

• エントリーDOI: 10.2210/pdb1riw/pdb
• 分子名称: thrombin light chain, thrombin heavy chain, B, thrombin heavy chain, C, ... (8 entities in total)
• 機能のキーワード: protease, thrombin, inhibitor complex, oscillarin, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 35512.36

構造登録者

Hanessian, S.,Tremblay, M.,Petersen, J.F.W. (登録日: 2003-11-18, 公開日: 2004-11-09, 最終更新日: 2020-07-29)

• 主引用文献: Hanessian, S.,Tremblay, M.,Petersen, J.F.W.; The N-acyloxyiminium ion aza-Prins route to octahydroindoles: total synthesis and structural confirmation of the antithrombotic marine natural product oscillarin; J.Am.Chem.Soc., 126:6064-6071, 2004; PubMed: 15137772; DOI: 10.1021/ja030669g

実験手法

X-RAY DIFFRACTION (2.04 Å)