1RGQ
M9A HCV Protease complex with pentapeptide keto-amide inhibitor
Summary for 1RGQ
Entry DOI | 10.2210/pdb1rgq/pdb |
Descriptor | NS3 Protease, NS4A peptide, ZINC ION, ... (4 entities in total) |
Functional Keywords | hepatitis c virus protease keto amide peptide inhibitor, viral protein, hydrolase |
Biological source | Hepatitis C virus More |
Cellular location | Core protein p21: Host endoplasmic reticulum membrane; Single-pass membrane protein (By similarity). Core protein p19: Virion (By similarity). Envelope glycoprotein E1: Virion membrane; Single-pass type I membrane protein (Potential). Envelope glycoprotein E2: Virion membrane; Single-pass type I membrane protein (Potential). p7: Host endoplasmic reticulum membrane; Multi-pass membrane protein. Protease NS2-3: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein. Non-structural protein 5A: Host endoplasmic reticulum membrane; Peripheral membrane protein. RNA-directed RNA polymerase: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential): P27958 |
Total number of polymer chains | 4 |
Total formula weight | 48076.96 |
Authors | Liu, Y.,Stoll, V.S.,Richardson, P.L.,Saldivar, A.,Klaus, J.L.,Molla, A.,Kohlbrenner, W.,Kati, W.M. (deposition date: 2003-11-12, release date: 2004-10-19, Last modification date: 2011-07-13) |
Primary citation | Liu, Y.,Stoll, V.S.,Richardson, P.L.,Saldivar, A.,Klaus, J.L.,Molla, A.,Kohlbrenner, W.,Kati, W.M. Hepatitis C NS3 protease inhibition by peptidyl-alpha-ketoamide inhibitors: kinetic mechanism and structure. Arch.Biochem.Biophys., 421:207-216, 2004 Cited by PubMed: 14984200DOI: 10.1016/j.abb.2003.11.013 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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