1RGQ

M9A HCV Protease complex with pentapeptide keto-amide inhibitor

1RGQ の概要

分子名称NS3 Protease, NS4A peptide, ZINC ION, ... (4 entities in total)
機能のキーワードhepatitis c virus protease keto amide peptide inhibitor, viral protein, hydrolase
由来する生物種Hepatitis C virus
詳細
細胞内の位置Core protein p21: Host endoplasmic reticulum membrane; Single-pass membrane protein (By similarity). Core protein p19: Virion (By similarity). Envelope glycoprotein E1: Virion membrane; Single-pass type I membrane protein (Potential). Envelope glycoprotein E2: Virion membrane; Single-pass type I membrane protein (Potential). p7: Host endoplasmic reticulum membrane; Multi-pass membrane protein. Protease NS2-3: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein. Non-structural protein 5A: Host endoplasmic reticulum membrane; Peripheral membrane protein. RNA-directed RNA polymerase: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential) P27958
ポリマー鎖数4
分子量合計48076.96
構造登録者
Liu, Y.,Stoll, V.S.,Richardson, P.L.,Saldivar, A.,Klaus, J.L.,Molla, A.,Kohlbrenner, W.,Kati, W.M. (登録日: 2003-11-12, 公開日: 2004-10-19, 最終更新日: 2011-07-13)
主引用文献
Liu, Y.,Stoll, V.S.,Richardson, P.L.,Saldivar, A.,Klaus, J.L.,Molla, A.,Kohlbrenner, W.,Kati, W.M.
Hepatitis C NS3 protease inhibition by peptidyl-alpha-ketoamide inhibitors: kinetic mechanism and structure.
Arch.Biochem.Biophys., 421:207-216, 2004
PubMed: 14984200 (主引用文献が同じPDBエントリー)
DOI: 10.1016/j.abb.2003.11.013
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (2.9 Å)
NMR情報
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構造検証レポート

ClashscoreRamachandran outliersSidechain outliersRSRZ outliers31.1%8.4%1.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
検証レポート(詳細版)をダウンロード