1RGQ

M9A HCV Protease complex with pentapeptide keto-amide inhibitor

1RGQ の概要

• エントリーDOI: 10.2210/pdb1rgq/pdb
• 分子名称: NS3 Protease, NS4A peptide, ZINC ION, ... (4 entities in total)
• 機能のキーワード: hepatitis c virus protease keto amide peptide inhibitor, viral protein, hydrolase
• 由来する生物種: Hepatitis C virus; 詳細
• 細胞内の位置: Core protein p21: Host endoplasmic reticulum membrane; Single-pass membrane protein (By similarity). Core protein p19: Virion (By similarity). Envelope glycoprotein E1: Virion membrane; Single-pass type I membrane protein (Potential). Envelope glycoprotein E2: Virion membrane; Single-pass type I membrane protein (Potential). p7: Host endoplasmic reticulum membrane; Multi-pass membrane protein. Protease NS2-3: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein. Non-structural protein 5A: Host endoplasmic reticulum membrane; Peripheral membrane protein. RNA-directed RNA polymerase: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential): P27958
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 48076.96

構造登録者

Liu, Y.,Stoll, V.S.,Richardson, P.L.,Saldivar, A.,Klaus, J.L.,Molla, A.,Kohlbrenner, W.,Kati, W.M. (登録日: 2003-11-12, 公開日: 2004-10-19, 最終更新日: 2011-07-13)

• 主引用文献: Liu, Y.,Stoll, V.S.,Richardson, P.L.,Saldivar, A.,Klaus, J.L.,Molla, A.,Kohlbrenner, W.,Kati, W.M.; Hepatitis C NS3 protease inhibition by peptidyl-alpha-ketoamide inhibitors: kinetic mechanism and structure.; Arch.Biochem.Biophys., 421:207-216, 2004; PubMed: 14984200; DOI: 10.1016/j.abb.2003.11.013

実験手法

X-RAY DIFFRACTION (2.9 Å)