1REC

THREE-DIMENSIONAL STRUCTURE OF RECOVERIN, A CALCIUM SENSOR IN VISION

Summary for 1REC

Entry DOI	10.2210/pdb1rec/pdb
Descriptor	RECOVERIN, CALCIUM ION (3 entities in total)
Functional Keywords	calcium-binding protein
Biological source	Bos taurus (cattle)
Total number of polymer chains	1
Total formula weight	23275.29
Authors	Flaherty, K.M.,Zozulya, S.,Stryer, L.,Mckay, D.B. (deposition date: 1993-10-29, release date: 1994-01-31, Last modification date: 2024-02-14)
Primary citation	Flaherty, K.M.,Zozulya, S.,Stryer, L.,McKay, D.B. Three-Dimensional Structure of Recoverin, a Calcium Sensor in Vision Cell(Cambridge,Mass.), 75:709-716, 1993 Cited by PubMed Abstract: Recoverin, a recently discovered member of the EF hand superfamily, serves as a calcium sensor in vision. We report here the crystal structure of recombinant unmyristoylated recoverin at 1.9 A resolution. The four EF hands of the protein are arranged in a compact array that contrasts with the dumbbell shape of calmodulin and troponin C. A calcium ion is bound to EF hand 3, while EF hand 2 can bind samarium but not calcium in this crystal form. The other two EF hands have novel structural features that prevent or impair calcium binding. A concave hydrophobic surface formed by EF hands 1 and 2 may participate in the read out of calcium signals by recoverin and its homologs. PubMed: 8242744 DOI: 10.1016/0092-8674(93)90491-8 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation