1REC

THREE-DIMENSIONAL STRUCTURE OF RECOVERIN, A CALCIUM SENSOR IN VISION

1REC の概要

• エントリーDOI: 10.2210/pdb1rec/pdb
• 分子名称: RECOVERIN, CALCIUM ION (3 entities in total)
• 機能のキーワード: calcium-binding protein
• 由来する生物種: Bos taurus (cattle)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 23275.29

構造登録者

Flaherty, K.M.,Zozulya, S.,Stryer, L.,Mckay, D.B. (登録日: 1993-10-29, 公開日: 1994-01-31, 最終更新日: 2024-02-14)

主引用文献

Flaherty, K.M.,Zozulya, S.,Stryer, L.,McKay, D.B.
Three-Dimensional Structure of Recoverin, a Calcium Sensor in Vision
Cell(Cambridge,Mass.), 75:709-716, 1993

PubMed Abstract: Recoverin, a recently discovered member of the EF hand superfamily, serves as a calcium sensor in vision. We report here the crystal structure of recombinant unmyristoylated recoverin at 1.9 A resolution. The four EF hands of the protein are arranged in a compact array that contrasts with the dumbbell shape of calmodulin and troponin C. A calcium ion is bound to EF hand 3, while EF hand 2 can bind samarium but not calcium in this crystal form. The other two EF hands have novel structural features that prevent or impair calcium binding. A concave hydrophobic surface formed by EF hands 1 and 2 may participate in the read out of calcium signals by recoverin and its homologs.

PubMed: 8242744
DOI: 10.1016/0092-8674(93)90491-8

実験手法

X-RAY DIFFRACTION (1.9 Å)