1RDR

POLIOVIRUS 3D POLYMERASE

1RDR の概要

• エントリーDOI: 10.2210/pdb1rdr/pdb
• 分子名称: POLIOVIRUS 3D POLYMERASE, CALCIUM ION (3 entities in total)
• 機能のキーワード: nucleotidyltransferase, poliovirus, 3d, rna-dependent, polymerase
• 由来する生物種: Human poliovirus 1
• 細胞内の位置: Protein VP2: Virion. Protein VP3: Virion. Protein VP1: Virion. Protein 2B: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 2C: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 3A: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 3B: Virion (Potential). Picornain 3C: Host cytoplasm (Potential). RNA-directed RNA polymerase 3D-POL: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential): P03300
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 52692.26

構造登録者

Hansen, J.,Long, A.,Schultz, S. (登録日: 1998-04-28, 公開日: 1998-09-16, 最終更新日: 2024-02-14)

主引用文献

Hansen, J.L.,Long, A.M.,Schultz, S.C.
Structure of the RNA-dependent RNA polymerase of poliovirus.
Structure, 5:1109-1122, 1997

PubMed Abstract: The central player in the replication of RNA viruses is the viral RNA-dependent RNA polymerase. The 53 kDa poliovirus polymerase, together with other viral and possibly host proteins, carries out viral RNA replication in the host cell cytoplasm. RNA-dependent RNA polymerases comprise a distinct category of polymerases that have limited sequence similarity to reverse transcriptases (RNA-dependent DNA polymerases) and perhaps also to DNA-dependent polymerases. Previously reported structures of RNA-dependent DNA polymerases, DNA-dependent DNA polymerases and a DNA-dependent RNA polymerase show that structural and evolutionary relationships exist between the different polymerase categories.

PubMed: 9309225
DOI: 10.1016/S0969-2126(97)00261-X

実験手法

X-RAY DIFFRACTION (2.4 Å)